STLO!

Karen R. recently vacationed in France. She passed through Normandy, it appears, and sent this photo. The motorist's options here: stay on the highway and continue towards CAEN, or take the Cherbourg Saint-Lô (STLO!) exit. St. Lô, you may recall from recent crossword clues, is on the Vire River, which rarely shows up in crosswords despite having a 4-letter, 50%-vowels name. Nice bonus having Vire on the sign, too.